ESR1 and breast carcinoma: Given that the YAP/TAZ pathway is associated with the epithelial-mesenchymal transition (EMT) in breast and other tissues (36) and the depletion of YAP inhibits TNBC invasion and proliferation (37), one may infer that IGFBP-3 is a link between less aggressive ERα positive breast cancer and more aggressive TNBC and antiestrogen-resistant breast cancer.