The rs1800497 and many other common variants in proximity to the DRD2 locus are significantly associated (p< 10-8 in GWA studies) with smoking (101), alcohol consumption (102), risk tolerance (103), schizophrenia (104), depression (105), suicide attempts (106), neuroticism (107), educational attainment (108), as well as cross-disorder (103) psychiatric disorders (8 diagnoses) (109). This evidence concerns the gene DRD2 and depressive symptom measurement.