TNF and Sepsis: Therefore, GC's potentiation of TNF-induction of CXCL10 in early/moderate sepsis and attenuation of LPS-induction of CXCL10 in hepatocytes during severe sepsis suggest that specifically activating hepatocellular GR to differentially modulate TNF- and LPS-induction of CXCL10 will be beneficial for both moderate and severe sepsis.