Plasma cells are normally recruited to the bone marrow for long-term residence through the CXCR4/SDF1 axis, however, MM cells overexpress CXCR4 leading to excessive bone marrow invasion (Mirandola et al., 2013; Ullah, 2019; Zannettino et al., 2005). This evidence concerns the gene CXCR4 and Miyoshi myopathy.