Autonomous interactions between malignant MM cells contribute to the perturbation of bone remodeling through Notch-mediated overexpression of RANKL and IL-6 as knockdown of Jagged1/Jagged2 in MM reduces their expression (Houde et al., 2004; Colombo et al., 2014, 2016). Here, JAG1 is linked to Miyoshi myopathy.