CXCR4 and Miyoshi myopathy: CXCR4 activation in MM cells activates pro-invasive genes, such as integrins, that allow for endothelial and bone marrow adhesion; cytoskeletal actin, which must be rearranged to allow for cellular flexibility; and matrix metalloproteinases (MMPs), which promote ECM degradation (Ullah, 2019; Parmo-Cabañas et al., 2004; Alsayed et al., 2007).