The CXCR4/SDF1 (CXC receptor 4/stromal derived factor 1) axis is a ubiquitous chemokine/seven pass GPCR signal transduction pathway represented in MM and many bone marrow metastatic cancers (Ullah, 2019; Otsuka & Bebb, 2008). This evidence concerns the gene CXCL12 and Miyoshi myopathy.