While the genetic origins of Notch dysregulation in MM are not completely understood and may vary between cases, its involvement in MM is widespread as 92% of patient samples express Notch1 and 92% of patient samples also express Jagged1 whereas normal post-germinal center plasma cells lack expression of these genes (Garis & Garrett-Sinha, 2021; Škrtić et al., 2010). This evidence concerns the gene JAG1 and Miyoshi myopathy.