Further research has shown that in vitro Jagged1/Jagged2 knockdown in cocultured MM cells decreases pre-osteoclast expression of Notch2, TRAP, RANK, and their autocrine expression of RANKL (Colombo et al., 2014; Schwarzer et al., 2008, 2014). The gene discussed is JAG1; the disease is Miyoshi myopathy.