In terms of major molecular events, HD MM may lead to dysregulated Notch signaling due to increased chromosomal copy number leading to overexpression of Notch1 (chr9), Notch3 (chr19), DLL3 (chr19), DLL4 (chr15), MAML1 (chr5), and MAML2 (chr11) (Colombo et al., 2015). The gene discussed is NOTCH1; the disease is Miyoshi myopathy.