In MM, bone remodeling is dysregulated in favor of resorption, which is likely driven evolutionarily as increased osteolysis leads to the release of matrix-bound growth factors such as insulin growth factor and transforming growth factor beta-1 (IGF and TGFB-1) (Coniglio, 2018; Morris & Edwards, 2021). The gene discussed is TGFB1; the disease is Miyoshi myopathy.