NOTCH2 and Miyoshi myopathy: For non-HD MM, overexpression of Notch can be attributed to translocations t(14;16) and t(14;20) which lead to the dysregulation of the transcription factors C-MAF and MAFB which both lead to downstream overexpression of Notch2 (Colombo et al., 2015; van Stralen et al., 2009).