Building on pioneering studies from a range of laboratories that established pro-inflammatory and pro-atherogenic roles for Egr-1 (20, 21), Manta and colleagues (22) studied links between Egr-1 and stabilin proteins in atherosclerosis using Apoe−/− mice interbred with stab1−/− and stab2−/− mice. The gene discussed is EGR1; the disease is atherosclerosis.