Egr-1/EGR1 was among the most significantly upregulated genes in human and murine vascular endothelial cells after ischemia (along with Jun, Zfp36, Fosb, and Hsp90aa1), findings supported by substantially greater EGR1+CD31+ double staining in coronary tissue from patients with ischemic cardiomyopathy compared with normal hearts (42). The gene discussed is EGR1; the disease is ischemic cardiomyopathy.