Additionally, PSME1/2/3 are implicated in MHC class I molecule-mediated antigen presentation [40], and their heightened expression is significantly correlated with the staging and prognosis of various tumors, including gastric [40], colorectal [41], clear cell renal cell carcinoma [42], and breast cancer [43]. The gene discussed is PSME1; the disease is clear cell renal carcinoma.