FAP and neoplasm: It is a membrane-bound protease with high expression in the tumor microenvironment of many solid cancer entities due to its presence on cancer-associated fibroblasts,42,43 a central component of the tumor microenvironment in primary and metastatic tumors.44 DOTAGA and SiFA represent the basis for radiolabelling in this radiohybrid example to prepare radioconjugates targeting FAP.