GRIA2 and Stroke: Study demonstrated that 8 weeks of high intensity interval trainingresults in an enrichment of miR-223 in the EVs of obese individuals [75].MiR-223 not only protected the brain from ischemia-inducedneuronal death following a stroke by inhibiting calcium influx in hippocampalneurons through the suppression of glutamate receptor 2 (GluR2) andN-methyl-D-aspartate receptor 2B (NR2B), but also mitigated inflammation bytargeting the NLRP3 inflammasome [80, 84].