The disturbed flow in vulnerable regionsprone to atherosclerosis enhances the expression and activities of protein kinaseAMP-activated catalytic subunit alpha 1 (PRKAA1/AMPKα1), which supportthe expression of HIF-1α and the transcription of glycolytic enzymes,ultimately promoting the glycolysis of VECs. The gene discussed is PRKAA1; the disease is atherosclerosis.