,55 One study showed that RNAi-mediated silencing of STAT3 and PD-L1 led to tumor growth inhibition by activating tumor-infiltrating immune cells, while RNAi-mediated silencing of STAT3/PD-L1 in tumor-associated immune cells induces robust antitumor effects in immunotherapy resistant tumors.54 This evidence concerns the gene CD274 and neoplasm.