In addition, it has been shown that FOXO1 increases MIR122 promoter activity by binding to the MIR122 promoter, which can be inhibited by leptin-induced phosphorylation of FOXO1 by the PI3K/Akt signaling pathway, and it was demonstrated that FOXO1 attenuates leptin-associated HSC activation and hepatic fibrosis in the ob/ob mouse model (34). This evidence concerns the gene FOXO1 and Hepatic fibrosis.