The diagnosis of NLRP3-AID can be made if raised acute phase reactants (CRP/SAA) can be detected in combination with at least two of the following clinical symptoms: urticarial-like rash (neutrophilic dermatitis), cold/stress-triggered episodes, sensorineural hearing loss, musculoskeletal symptoms (arthritis, arthralgia or myalgia), chronic aseptic meningitis and skeletal abnormalities (epiphyseal overgrowth, frontal bossing), even in absence of genetic confirmation (57). Here, CRP is linked to arthritic joint disease.