•Recurrent fevers without apparent infectious causes •Periodic fevers with a predictable pattern•Poor response to antibiotics•Mouth or genital ulcers•Lymphadenopathies•Signs of serositis or arthritis•Unexplained rashes, especially in association with fever episodes•Elevated inflammatory markers (e.g., CRP, ESR) during and between episodes•Family history of autoinflammatory disorders•Ethnic background associated with certain autoinflammatory diseases (e.g., Mediterranean descent for Familial Mediterranean Fever)•Young age at the onset of disease flares•Failure to thrive. Here, CRP is linked to familial Mediterranean fever.