CRP and Arthritis: The diagnosis of NLRP3-AID can be made if raised acute phase reactants (CRP/SAA) can be detected in combination with at least two of the following clinical symptoms: urticarial-like rash (neutrophilic dermatitis), cold/stress-triggered episodes, sensorineural hearing loss, musculoskeletal symptoms (arthritis, arthralgia or myalgia), chronic aseptic meningitis and skeletal abnormalities (epiphyseal overgrowth, frontal bossing), even in absence of genetic confirmation (57).