ACE2 and infection: These signals include transforming growth factor beta (TGFβ); interleukin 10 (IL-10); interleukin 1 (IL-1) receptor agonist; and high-density lipoprotein cholesterol (HDL-C), anti-inflammatory cytokines along with vast expression of angiotensin-converting enzyme 2 (ACE2) receptors within endothelial cells, which can cause SARS-CoV-2-binding endothelial compartments; fusion to membrane; viral entry; infection; vascular injury; and disequilibrium and dysfunction of the endothelial environment [10].