CHF: chronic heart failure, CKD: chronic kidney disease, HTN: hypertension, T1DM: type 1 diabetes mellitus, T2DM: type 2 diabetes mellitus, DM: diabetes mellitus, NASH: nonalcoholic steatohepatitis cirrhosis, AF: atrial fibrillation, GI: glucose and insulin, AVB: atrioventricular block, RBBB: right bundle branch block. Here, INS is linked to type 1 diabetes mellitus.