Among them, the top 5 most active KEGG pathways in the healthy group were pathways in cancer, neurotrophin signaling pathway, regulation of actin cytoskeleton, fc gamma r mediated phagocytosis, and leukocyte transendothelial migration (Figure 3(a)), while the top 5 most active KEGG pathways in the VTE group were ribosome, Parkinson's disease, oxidative phosphorylation, Alzheimer's disease, and Huntington's disease (Figure 3(b)). The gene discussed is BDNF; the disease is early-onset autosomal dominant Alzheimer disease.