IL6 and Abnormal emotional state: Previous studies have shown that the experience of negative life events may result in increased levels of pro-inflammatory markers, mainly IL-6 and CRP, via psychological distress (Baumeister, Akhtar, Ciufolini, Pariante, & Mondelli, 2016; Flouri, Francesconi, Papachristou, Midouhas, & Lewis, 2019).