SIRT6 and Cholestatic liver disease: Sirtuin 6 (SIRT6), a member of the sirtuin family, possesses nicotinamide adenine dinucleotide-dependent deacetylase, mono-adenosine diphosphate-ribosyltransferase, and long-chain fatty acyl deacylase activities[10–11], and regulates a variety of biological functions, including oxidative stress, inflammation, and mitochondrial biology[12], which are involved in the development of cholestatic liver disease.