SELPLG and autoimmune disease: It has been found that skin-resident immune cells in PSGL-1 -/- mice have a pro-inflammatory phenotype, with a disproportionate ratio of T effector to Tregs, and that mouse serum contains circulating autoantibodies commonly found in human autoimmune disorders, which ultimately leads to overactivation of the immune system triggering an autoimmune disease similar to SSc [68].