Drawbacks of carotid body stimulation include dependence on an external programming device for the pulse generator, the fact that it is unsuitable for certain types of HTN such as angiotensin II-induced HTN, and the fact that medication treatment is still required for carotid body stimulation to be effective; a case report showed BP rises when stimulation was conducted without antihypertensive medications, and the signature decrease in BP is only present when antihypertensive medications are used in tandem with carotid body stimulation. This evidence concerns the gene AGT and hypertensive disorder.