AMBRA1 has been described as a tumor suppressor in diffuse large B-cell lymphoma (DLBCL) [40], lung adenocarcinoma (LUAD) [41, 42], melanoma [43], and these entities may harbor mutations in AMBRA1. While it is surprising that ATRT do not seem to harbor AMBRA1 mutations [9, 11], both loss-of-function studies in ATRT cells as well as genetic interaction analyses from DepMap performed in this study strongly support a tumor suppressive role of AMBRA1 in neural crest derivatives including melanoma and rhabdoid tumors. The gene discussed is AMBRA1; the disease is diffuse large B-cell lymphoma.