Of note, cyclin A2 and cyclin B1 levels were not significantly altered in this comparison, suggesting that upregulation of G2/M phase regulators in AMBRA1 responder cells is not due to an increase in G2/M phase cells per se, but instead might have functional relevance for the context-dependent tumor suppressive activity of AMBRA1 in those cells. This evidence concerns the gene CCNB1 and neoplasm.