A recent experimental study demonstrated in vitro that that human spermatozoa are susceptible to SARS-CoV-2 infection, showing a high expression of ACE2 and co-receptors TMPRSS2, Basigin and Cathepsin L. Moreover, authors have found subcellular sites of viral replication by transmission electron microscopy analysis on the ejaculated semen of a COVID-19-affected man (not included in the review for the absence of a PCR test) [48]. Here, TMPRSS2 is linked to COVID-19.