GPC1 and colorectal carcinoma: The exosomal cargo protein QSOX1 is significantly reduced in the blood of tumor patients compared with healthy human controls while Glypican-1 (GPC1) is significantly increased in exosomes, and a series of recent studies have suggested that dysregulation of exosomal proteins could serve as a promising novel biomarker for the early diagnosis and non-invasive risk stratification of CRC.145 At present the monitoring of single extracellular vesicles (SEV) is also helpful in the diagnosis of colorectal cancer.