For example, neuron-specific enolase, basic fibroblast growth factor (bFGF), and hyaluronidase are enriched in the urine of patients with nephroblastoma and can be used as indicators for the diagnosis of WT.360,361 In addition, in the monitoring of the therapeutic efficacy of WT as well as in the determination of the prognosis, several protein biomarkers, such as transgenic specific enolase (NSE), hyaluronic acid (HA), hyaluronan-stimulating activity (HSA), and hyaluronidase, etc. can be used as assays to assist in the judgment.360,362. The gene discussed is ENO2; the disease is Wilms tumor.