Furthermore, NETs released from systemic lupus erythematosus (SLE) neutrophils contain bioactive IL-33, and these NETs decorated with bioactive IL-33 stimulate robust IFN-α synthesis.49 The research mentioned above, along with our results, demonstrates a close association of IL-33 with NETs in autoimmune diseases. The gene discussed is IL33; the disease is systemic lupus erythematosus.