Considering the elevated expression of IGF2BP1, 2, and 3 in HCC tissues relative to normal tissues (Fig. 4b), we posited that these factors modulated the stability of EPHA3 mRNA, a hypothesis supported by predictive analyses, which indicated robust binding affinity of IGF2BPs to EPHA3 mRNA (Supplementary Fig. 4a). The gene discussed is EPHA3; the disease is hepatocellular carcinoma.