HIF1A and cancer: EGF-dependent ERK activation reportedly enhances expression of the glycolytic genes GLUT1 and LDHA and subsequent glycolysis, although the detailed mechanisms remain to be investigated.59 IGF1 increases glycolysis possibly through HIF1α, a key regulator of glycolysis, because IGF1 stimulates HIF1α expression.10 IGF1 induction of HIF-1α in cancer cells is blocked by treatment with inhibitors targeting the PI3K and MAPK pathway.