Interestingly, GDC treatment not only ameliorated the anemic phenotype in peripheral blood but also reversed the anemia-induced erythropoiesis shift in the bone marrow, restoring it to normal levels comparable to the control group without modeling, with an enhanced population of CD71+ Ter119+ erythroblasts (Supplementary Fig. 9e, f). Here, TFRC is linked to anemia (phenotype).