Different NPS have been related to different neurodegenerative processes and by extension to heterogeneous cognitive trajectories and progression to different neurocognitive entities; for instance, psychosis has been linked to neuritic plaques, neurofibrillary tangles and Lewy body disease (and in turn to AD and Lewy body dementia ‐LBD), whereas agitation and aggression have been associated with TDP‐43 pathology (a common substrate of FTD) [16]. The gene discussed is TARDBP; the disease is Lewy body dementia.