For example, in response to molecularly targeted therapy, a cancer cell either conducts apoptosis or repairs the damage (15, 16); in response to a morphogen, a cell either maintains its original identity or turns into a new type of cell (17, 18); in response to insulin stimulus, a myocyte either takes up glucose all-out or abstains from glucose uptake, again an all-or-none response (14, 19, 20, 21); in response to steroid stimulus, the transcription in a single cell is either activated or not, and it occurs in bursts (22, 23, 24). Here, INS is linked to cancer.