INS and obesity due to melanocortin 4 receptor deficiency: For example, Figure 4, A1 and B1 show the insulin response of the whole-body and the legs, respectively, of individuals with leanness (blue), obesity (green), and diabetes (red) (45); both have the same order of ρ(θ) from left to right: lean → obese → diabetic, indicating the strengthening of insulin resistance as the disease progresses.