PDIA3 and obesity due to melanocortin 4 receptor deficiency: This finding highlights an underappreciated role of the mechanosensing immune cells [244] and PDIA3 self-antigens in mediating a mechano-redox control of inflammation, especially during obesity and aging, where the VAT and the liver exhibit increased tissue stiffness due to hypertrophy, extracellular matrix accumulation, and fibrosis [245–248].