LDLR and Alzheimer disease: Moreover, our GRN analysis showed that the PARP14 node was linked to PARP1 and SIRT1. Whereas no studies to date investigated the function of PARP14 in AD, lipid studies have reported that PAPR14 regulates low-density lipoproteins (LDL) receptors and apolipoproteins in macrophages, thus involved in hypercholesterolemia and hyperlipidemia [52].