After FDR correction, 12 of these genes (2 up-regulated [SLC7A5, DHTKD1] and 10 down-regulated [TDO2, HAAO, AOC1, GOT2, IDO2, DLD, SLC7A5, WARS, CYP2E1, DHCR24, KYAT3]) showed significant differential mRNA expression in patients with AD versus controls (Fig. 1A; Table S4). This evidence concerns the gene TDO2 and Alzheimer disease.