YAP transcriptional regulator mediates resistance to RAF and mitogen-activated protein kinase (MAPK) kinase (MEK)-targeted cancer therapies [17], YAP and TAZ mediate resistance of melanoma cells to BRAF inhibitors [18], whereas recent findings reveal that Piezo1 mechano-induced ion channel regulates myeloid cells to control innate immunity against cancer [19]. The gene discussed is WNK2; the disease is cancer.