Furthermore, given the role of ASGR1 in modulating the recognition of desialylated glycoproteins, which are highly abundant during infection and inflammatory conditions [15], we focused our attention on the investigation of the effect of ASGR1 deficiency on the immunoinflammatory response observed during atherogenesis and appreciated an increase in the inflammatory signature while the plasma N-glycome remained stable during atherogenesis. The gene discussed is ASGR1; the disease is infection.