At 8 weeks after delivery, the content of chemerin in serum of maternal mice recovered to the pre-pregnancy level, and there was no statistical difference in blood glucose between different groups of mice and its offspring, which confirmed that our GDM model presented transient changes in glucose intolerance during pregnancy, and also indicated that chemerin administration had no long-term effect on the blood glucose of mother and child. The gene discussed is RARRES2; the disease is Glucose intolerance.