We note that 6 of the 20 SNORD116-specific mRNAs (ADCYAP1, KLHL14, HMGCLL1, PCDHGB7, ZBTB20, APLNR) were differentially expressed in samples from PWS patients (Bochukova et al. 2018) but not always in the same direction. This evidence concerns the gene ZBTB20 and Prader-Willi syndrome.