We note that 6 of the 20 SNORD116-specific mRNAs (ADCYAP1, KLHL14, HMGCLL1, PCDHGB7, ZBTB20, APLNR) were differentially expressed in samples from PWS patients (Bochukova et al. 2018) but not always in the same direction. Here, APLNR is linked to Prader-Willi syndrome.