FLT3 and acute myeloid leukemia: First, a stable iASPP shRNA knock-down was established in the TP53 wt, mutant FLT3-internal tandem duplication (ITD) AML cell line MOLM14, which mimics FLT3-mutated AML (in which high levels of iASPP predict for poor survival, see Supplementary Fig. S1).