To assess whether the clinical observations linked to high iASPP expression directly translate into genuine functional consequences, several leukemia iASPP-interference models were generated for in vitro, ex vivo and in vivo assessment, including patient leukemic blasts as well as a TP53 wt (MOLM14) and a TP53 null (HL60) cell line model. This evidence concerns the gene PPP1R13L and leukemia.