PPP1R13L and acute myeloid leukemia: Next, iASPP levels were determined in patients with newly diagnosed AML (n = 42) and patients with relapsed or refractory (R/R) AML (n = 10) - with significantly higher mean iASPP levels detected in patients with R/R AML than in the cohort of patients with de novo AML (p = 0.0450), (Fig. 1H).