To assess whether the in vitro observations with regard to altered proliferation rates in iASPP-interferenced leukemia cells translate into reduced tumor engraftment and disease progression in vivo, a MOLM14_iASPP KD_Luc+ xenotransplant NSG mouse model was established: 6 weeks old mice were injected IV with stably iASPP-interferenced cell strains or the EV mock controls. The gene discussed is PPP1R13L; the disease is neoplasm.