SMPD3 and diabetes mellitus: In this study, we first found that the expression of Smpd3 in jawbone-derived BMSCs from patients with diabetes was reduced, Smpd3 knockdown inhibited the osteogenic differentiation of BMSCs from patients with diabetes, and Smpd3 overexpression significantly promoted the osteogenic differentiation of BMSCs from patients with diabetes, indicating that Smpd3 plays a role in promoting the osteogenic function of jawbone-derived BMSCs from patients with blood glucose fluctuations.