Through proteomics, we found that Smpd3 may be expressed at low levels in jaw-derived BMSCs from individuals with T2DM, and combined with animal experiments, these data showed that Smpd3 is also expressed at low levels in the bone healing tissue of GK rats.22,23 These findings indicate that Smpd3, as an endogenous protein, has good potential in modifying stem cell exosomes to promote blood glucose fluctuations in bone regeneration, but its function and regulatory mechanism are still unclear. Here, SMPD3 is linked to type 2 diabetes mellitus.