MAPT and tauopathy: According to the amyloid cascade hypothesis, AD follows a pathological sequence of events that starts with Αβ peptide accumulation, aggregation, and amyloid formation extracellularly within the brain.25, 26, 27 This subsequently elicits a tauopathy in which hyperphosphorylated tau oligomerizes and then aggregates as neurofibrillary tangles (NFT) within neurones, which eventually causes neurological disease.