HSP90AB1 and Alzheimer disease: Typically, late-onset disease is a consequence of age-related changes in combination with a variety of associated risk factors, whereas early onset disease is normally due to genetic mutations that are associated with AD.3, 4 Rewiring of the chaperone system into epichapromes, which consist of the major heat shock proteins such as Hsp90 together with scaffolding and regulatory proteins, is able to assist cell survival under the elevated proteome demand, which is thought to propagate the progression of AD.5, 6, 7, 8, 9