The significance of deranged expression of HSPs and various chaperones in AD cases has been reported,78, 79, 80 and it has been shown that 17-AAG, an Hsp90 ATPase inhibitor, can attenuate Aβ toxicity and prevent memory loss in the Tg2576 transgenic AD mice model.81 This evidence concerns the gene HSP90AB1 and Alzheimer disease.