TTR and amyloidosis: Notably, a study that treated a transgenic mouse model for TTR-amyloidosis with carvedilol, a β-blocker with strong antioxidizing effects, found a reduction in both 4-hydroxy-trans-2-nonenal adducts and 8-hydroxy-2′deoxyguanosin adducts, as well as the total load of TTR deposits (69).