This reflects that one tissue with substantial levels of GPR35 is the colon (47, 48, 49, 50), that in the majority of studies elimination of GPR35 from mice increases severity of Dextran-Sodium Sulphate-induced colitis and that drugs that are used in this area, including amino-salicylates, target GPR35 to generate at least part of their effect (17, 27). This evidence concerns the gene GPR35 and colitis.