Given that the RNA‐seq results of Mettl16‐sKO and Ythdc1‐sKO testes indicate that only a few of DEGs are directly related to the differentiation of spermatogonia, the absence of these two factors is more likely to cause abnormalities in chromosomal organisation and segregation, induce apoptosis in differentiating spermatogonia, and ultimately lead to male infertility. The gene discussed is YTHDC1; the disease is male infertility.