Osterburg et al. [71] found that NKG2DLs (ULBP3 and/or ULBP2) were detected in human lung LAM cells, but not in normal lung tissues surrounding LAM lesions and soluble ULBP2(mean = 575 pg/ml ± 142) and ULBP3(mean = 8300 pg/ml ± 1515) were increased in serum of LAM patients. The gene discussed is ULBP3; the disease is lymphangioleiomyomatosis.