Meanwhile, increased CATK expression in LAM nodular tissue was associated with decreased FEV1 (95%CI -1.11 to -0.18) and DLco (95%CI -0.96 to -0.05) [49], suggesting that the aggregation of LAM fibroblasts led to CATK overexpression. The gene discussed is TSC1; the disease is lymphangioleiomyomatosis.