Our transcriptomic integration showed that the Wnt signaling co-receptors LRP5 and LRP6 (Fig. 2A, F and G) and non-canonical Wnt signaling through VANGL2 are all upregulated at the transcriptomic level and, in BOS samples, also at the protein level [28]. The gene discussed is VANGL2; the disease is Buschke-Ollendorff syndrome.