An independent study comparing AML-ASXL1 to AML without ASXL1 variants also identified VANGL2, LRP5 and LRP6 as three of the most significantly upregulated genes using a limited microarray probe-set [51], supporting that aberrant Wnt signaling occurs in the presence of ASXL1 pathogenic variants. The gene discussed is LRP5; the disease is acute myeloid leukemia.