Many of the exons with significant DEU in AML-ASXL1 blood had immune- or cancer-related function, such as TBL1X/Y related 1 (TBL1XR1), DEAD-box helicase 42 (DDX42), Rho associated coiled-coil containing protein kinase 1 (ROCK1), neurobeachin like 2 (NBEAL2), and UDP-glucose pyrophosphorylase 2 (UGP2) (Table S7). Here, TBL1XR1 is linked to acute myeloid leukemia.