ASXL1 and acute myeloid leukemia: DNAm analysis further identified hypomethylation at specific CpG sites upstream of the HOXA11 TSS (cg00705992 and cg16038003) in BOS and AML-ASXL1 samples, supporting literature that truncating ASXL1 variants lead to derepression of posterior HOXA genes (Fig. 3E and S4A).