Similarly, we identified significant upregulation of LRP5 (BOS log2FC = 1.64, AML-ASXL1 log2FC = 2.65) (Fig. 2F) and LRP6 (BOS log2FC = 1.63, AML-ASXL1 log2FC = 2.21) (Fig. 2G) in both BOS and AML-ASXL1 samples. Here, ASXL1 is linked to acute myeloid leukemia.