Many of the exons with significant DEU in AML-ASXL1 blood had immune- or cancer-related function, such as TBL1X/Y related 1 (TBL1XR1), DEAD-box helicase 42 (DDX42), Rho associated coiled-coil containing protein kinase 1 (ROCK1), neurobeachin like 2 (NBEAL2), and UDP-glucose pyrophosphorylase 2 (UGP2) (Table S7). The gene discussed is ASXL1; the disease is acute myeloid leukemia.