In contrast, myeloid malignancies– including chronic myelomonocytic leukemia (CMML), myelodysplastic syndromes (MDS), myeloproliferative neoplasms, and both secondary and de novo AML [5–8], exhibit a diverse genetic mutational landscape of which somatic variants of ASXL1 are frequently observed. The gene discussed is ASXL1; the disease is chronic myelomonocytic leukemia.