That is not to say that one AKT isoform cannot reside in more than one subcellular compartment, as AKT1 and AKT2 have been detected in the nucleus of breast cancer cells [29], as well as the cytoplasm or mitochondria [26], which makes ascribing a single function to a particular isoform in such cellular contexts quite difficult. Here, AKT1 is linked to breast cancer.