AKT1 and cancer: Once activated, Akt dissociates from the cell membrane and is transported to the cytosol, nucleus, or mitochondria, where it phosphorylates and activates or inhibits numerous downstream effectors, many of which contain the consensus phosphorylation sequence RxRxxS/T, culminating in cell growth, metabolism, migration, survival, cell cycle progression, and angiogenesis, processes that constitute cancer hallmarks and are frequently deregulated in cancer cells [9, 80].