In papillary thyroid cancer, SIRT7, an NAD + -dependent histone/non-histone deacetylase, may be targetable, as it often shows increased expression; SIRT7 suppresses the transcription of DBC1, an endogenous inhibitor of SIRT1, by deacetylating H3K18Ac. This evidence concerns the gene SIRT7 and thyroid gland papillary carcinoma.