Like pan-AKT inhibitors, it is not entirely clear what the mechanism of action of A-674563 in tumor cells is since it increased (PRAS40) or had no effect (GSK3β) on the phosphorylation of substrates shared by all AKT isoforms, although it is expectedly decreased the phosphorylation of FOXO1 [342]. This evidence concerns the gene AKT1 and neoplasm.