TRPM7 and amyotrophic lateral sclerosis: TRPM7 is also involved in susceptibility to ALS-PDC (Amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam), and the residue mutated in human TRPM7 (red arrowhead on Fig. 3c) is conserved in the vertebrate TRPM6 and − 7, except for in salmon Trpm6-1 and 6 − 2 and fugu Trpm6.