We found ART events affecting genes known to impact tumor proliferation or metastatic potential that were shared or unique to different metastatic clades (Fig. 4d and Extended Data Fig. 8); for example, ART of PDL1 and PIK3CA was shared by all clones, ART of CDK12 was only present in the right phylogenetic branch comprising the second and third clades and ART of KRAS was mostly exclusive to the most proliferative third clade. The gene discussed is CDK12; the disease is neoplasm.