Other genes were shown to be frequently altered in HNSCC, including FAT1 (22%) and FLG (19%) in 104 HNSCCs and MLL2 (17%), FGFR3 (5–7%), and HRAS (4%) in 88 HNSCCs [1] [6] [22], or were shown to be significantly enriched, such as KMT2D, NSD1, CASP8, AJUBA, TGFBR2, HLA-A, TPRX1, CUL3, FLG, NSD1, DDX3X, RPIK4, KRAS, MLL3, FGFR2, ZNF217, and RIMS2 [4] [7, 8]. The gene discussed is FAT1; the disease is head and neck squamous cell carcinoma.