CDKN2A mutations or deletions, TP53 mutations, CCND1 and FGFR1 amplifications, alterations in the cell cycle and PIK3/AKT/MTOR pathways and more than 3 genomic alterations negatively impact the overall survival of HNSCC patients [56]. The gene discussed is PIK3CG; the disease is head and neck squamous cell carcinoma.