Typically, during the process of ICD, dying cells release DAMPs, including surface-exposed calreticulin (ecto-CRT), high mobility group protein B1 (HMGB1), and adenosine triphosphate (ATP), which facilitate the phagocytosis of tumor cells by antigen-presenting cells (APCs) to promote tumor-specific immune responses. The gene discussed is HMGB1; the disease is neoplasm.