To further validate this finding, we isolated bulk CD8 + T cells from LTS patients, as well as CXCR3 + and CXCR3- CD8 + T cell subsets from paired PB and BM samples of newly diagnosed MM patients, and performed RNA-sequencing, followed by mapping the T cell receptor (TCR) repertoire (Supplementary Fig. 6b, d). Here, CD8A is linked to Miyoshi myopathy.