CXCL8 and plasma cell myeloma: As part of the inflammatory response, ‘aberrant-like’ monocytes displayed an increased chemokine activity and expressed increased levels of proinflammatory cytokines and chemokines, including CCL3, IL1B and CXCL8, with the latter two known to support myeloma cell growth and survival (Fig. 4d, e and Supplementary Fig. 5a–e)23.