KANK1 and in situ carcinoma: To decipher the potential oncogenic function of KANK1, we induced breast cancer by crossing KANK1-WT and KANK1-KO mice with the polyoma middle-T (PyMT) mouse luminal breast cancer model that closely recapitulates human breast cancer development and progression from hyperplasia and early carcinoma in situ to invasive carcinoma49.