To decipher the potential oncogenic function of KANK1, we induced breast cancer by crossing KANK1-WT and KANK1-KO mice with the polyoma middle-T (PyMT) mouse luminal breast cancer model that closely recapitulates human breast cancer development and progression from hyperplasia and early carcinoma in situ to invasive carcinoma49. Here, KANK1 is linked to breast cancer.