NOS1 and breast cancer: NOS1AP can bind and activate dexamethasone-induced Ras-related protein 1 (Dexras1) leading to enhanced neuronal nitric oxide synthase (nNOS) signaling42, synapsins I-III leading to nNOS localization to presynaptic terminals43, and SCRIB leading to increased dendritic spine formation in cultured hippocampal neurons44 and inhibition of YAP activity in the breast cancer cell line MCF736.