Although we demonstrate that expression of TAZSSAA in MCF7KANK1-KO tumoroids reversed the growth retardation of non-transduced MCF7KANK1-KO tumoroids, xenografting TAZSSAA-expressing MCF7KANK1-KO cells in vivo will constitute strong evidence for KANK1 inhibition as a potential therapeutic strategy to curb breast cancer growth in patients. This evidence concerns the gene KANK1 and breast carcinoma.