287 Karagiannis Karagiannis T. T. Avgerinos Avgerinos I. I. Liakos Liakos A. A. Del Prato Del Prato S. S. Matthews Matthews D.R. D.R. Tsapas Tsapas A. A. Management of type 2 diabetes with the dual GIP/GLP-1 receptor agonist tirzepatide: a systematic review and meta-analysis Management of type 2 diabetes with the dual GIP/GLP-1 receptor agonist tirzepatide: a systematic review and meta-analysis Diabetologia. The gene discussed is GIP; the disease is type 2 diabetes mellitus.